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The first use in warfare of a nuclear weapon occurred on August 6, 1945, at 8:16:02 a.m. over Hiroshima, Japan. In an instant 80,000 to 140,000 people were killed and 100,000 more were seriously injured. Hiroshima ceased to exist as a functioning city. The bomb exploded almost directly over the center of the city. Two square miles of the city were completely leveled by the bomb.